Treating Cancer by Targeting Gene Mutations

Grant number: 1002654 | Funding period: 2011 - 2015

Completed

Abstract

Major advances in cancer treatment has been made by identifying gene mutations in cancers to which the cancer is “addicted”, such that turning off the effects of the mutations leads to death of the cancer cells. Grant McArthur has been successful in applying this principle to rare types of sarcoma bringing his work to routine clinical practice globally. In this application he will investigate targeting the BRAF, KIT and MYC genes focusing on melanoma, a major cancer problem in Australia.

Related publications (4)

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Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies

AJ Colebatch, LD Stefano, SQ Wong, RD Hannan, PM Waring, A Dobrovic, GA McArthur, AT Papenfuss

2016-01-01

Most cancer DNA sequencing studies have prioritized recurrent non-synonymous coding mutations in order to identify novel cancer-re..

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Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome

LY Tan, C Mintoff, MZ Johan, BW Ebert, C Fedele, YF Zhang, P Szeto, KE Sheppard, GA McArthur, E Foster-Smith, A Ruszkiewicz, MP Brown, CS Bonder, M Shackleton, LM Ebert

2016-01-01

Tumors can develop a blood supply not only by promoting angiogenesis but also by forming vessel-like structures directly from tumo..

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Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma

SQ Wong, A Behren, VJ Mar, K Woods, J Li, C Martin, KE Sheppard, R Wolfe, J Kelly, J Cebon, A Dobrovic, GA McArthur

2015-01-01

Melanoma is often caused by mutations due to exposure to ultraviolet radiation. This study reports a recurrent somatic C > T chang..

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Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma

VJ Mar, SQ Wong, A Logan, T Nguyen, J Cebon, JW Kelly, R Wolfe, A Dobrovic, C Mclean, GA Mcarthur

2014-11-01

Activating mutations in the GTPase RAC1 are a recurrent event in cutaneous melanoma. We investigated the clinical and pathological..

University of Melbourne Researchers